The main purpose of keeping a science notebook is to assist students with taking responsibillity for their own learning. Here is the checklist I use when I look through student notebooks:
- Question of the Day and Date at the top of the page
- QOD is answered and boxed.
- Reflection / Connection questions are answered in complete sentences.
- Labs are completed with an organized data table and analysis of results
- Diagrams/graphs are clear, accurate, labeled, and describe "what it means" in student's own words
- Effort is evident in the notebook by neatness, organization, and response to teacher's feedback.
Question of the Day: How does the chloride channel defect cause symptoms of cystic fibrosis?
Activity: Students are analyzing the results of an osmosis lab involving sodium chloride. Their conclusions should relate to the biology of the disease cystic fibrosis. Students will explain and evaluate why imbalance in salt concentration causes disease and/or dehydration in the human body.
Assessment: Students' answers to the Analysis Questions listed below:
Student's Evaluation of Alternative Explanations
Read the information below about cystic fibrosis and respond with a 1 paragraph summary of how chloride channel proteins are responsible for the accumulation of mucus in a CF individual's lungs"
After the osmosis lab, your conclusion led to an understanding of how chloride was unable to leave epithelial cells and as a result, the Cl- ion concentration is higher within epithelial cells which then take up water resulting in thick, dehydrated mucus.
Another explanation for CF is that NaCl concentrations are HIGHER OUTSIDE the epithelial cells. This high NaCl concentration prevents antibiotics in the respiratory tract from working, resulting in repeated respiratory tract infections.
Since these 2 explanations are opposite, or contradictory, to one another, scientists are unable to say with 100% certainty what causes cystic fibrosis.
Which explanation DO YOU AGREE with? Use at least 2 pieces of evidence from your lab to support your answer. .
What piece of evidence from CF patients would help us to know what the cause of the disease is? (what could we measure in their cells?) Salt concentration in expelled mucus CAN be measured, but varies greatly and may not reflect what is inside the patient.
Links to Cystic Fibrosis: Both Sides of the Controversy
Chloride Channel Defect
http://www3.interscience.wiley.com/journal/117924909/abstract?CRETRY=1&SRETRY=0
Respiratory Infections from Bacteria
http://www.biotech-weblog.com/50226711/scientists_identify_key_target_to_kill_cystic_fibrosis_bug.php
Please post your answers as comments on the blog.
No comments:
Post a Comment